Determination of essential and toxic metals in blood by ICP-MS using calibration in a synthetic matrix
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چکیده
A method used to determine Pb in unknown matrices by isotope dilution mass spectrometry (IDMS) was previously published by NIST [1]. IDMS is considered the most accurate method for total blood metals analyses, mainly because it eliminates the blood’s matrix effect [2, 3]. However, the IDMS method is relatively expensive, and cannot be used for mono-isotopic metals such as Mn or As. Alternatively, the use of internal standards (ISTDs) can compensate for matrix effects by correcting the analyte response Determination of essential and toxic metals in blood by ICP-MS using calibration in a synthetic matrix
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